Carefully implemented childhood cancer programs in LMICs have documented improvements in survival rate of 30%, within less than a decade. Another effective strategy is that of “twinning programs”. Sustained partnership with centers of excellence in developed countries or other middle income countries with advanced capacities , and modest investment of funding, mentoring, training, and support for key personnel in the LMIC center, effectively complement top‐down efforts to improve national healthcare coverage and national cancer control efforts for children. Recent researches in Africa and Central America also revealed that investment in curing highly cureable and common cancers like acute lymphoblastic leukemia and Burkitt lymphoma is extremely cost‐effective, even in LMIC. Researches in the USA have shown that without making a single new discovery, 30% more teens with cancer could be cured simply by giving them pediatric – instead of adult – treatments.